NS resuscitation required 7 times more fluid (50.9 ± 7.7 vs. Total tissue water (TW) was measured from wet and dry weights interstitial fluid volume (ISFV) and cell water were calculated. A 2-h 51Cr-EDTA distribution space estimated extracellular fluid volume (ECFV), and a 5-min 125I-labeled albumin distribution space measured plasma volume (PV). ![]() Nephrectomized, anesthetized rats were bled to 50 mmHg mean arterial pressure for 1 h, followed by 60 min of resuscitation to restore blood pressure using 0.9% normal saline(NS, n = 10), 7.5% hypertonic saline(HS, n = 8), 10% hyperoncotic albumin (HA, n = 8), or 7.5% hypertonic saline and 10% hyperoncotic albumin (HSA, n = 7). We measured how shock and resuscitation acutely alters the interstitial, cellular, and plasma compartments in different organs. In conclusion, 1 ) HS solutions mobilize fluid from cells while expanding both PV and ISFV, and 2 ) TW and cellular water increase with both isotonic crystalloids and hyperoncotic colloids in many tissues.Ībstract = "Postresuscitation organ failure may be associated with detrimental changes in body fluid compartments. In all tissues, mean cell water in groups receiving HS was smaller this was significant for heart, lung, muscle, and skin. ![]() ISFV was significantly reduced by HA groups in the skin. TW was significantly reduced by hypertonic saline groups in heart, muscle, and liver (P < 0.05). Fluid shifts within tissues depended on resuscitation solution and type of tissue. 8.6 ± 0.7 for HA, 5.9 ± 0.4 for HS, and 3.9 ± 0.5 ml/kg for HSA), but there were no differences between solutions in whole animal PV, ECFV, or ISFV. ![]() Postresuscitation organ failure may be associated with detrimental changes in body fluid compartments.
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